Owing to the decreased muscle mass, the elderly affected people may have an elevated BUN:Cr ratio at baseline. Low BUN creatinine levels, where the BUN-creatinine ratio is less than 10:1, indicates reduced reabsorption of BUN due to renal damage. The normal BUN values should be 5-15 mg/dL for children, 8-23 mg/dL for the adults, and 5-12 mg/dL during pregnancy.Ī BUN-creatinine ratio greater than 20:1, is referred to as elevated BUN and creatinine levels which is usually noticed when the glomerular filtration rate (GFR) decreases. In case of babies, younger than twelve months, the ratio can be around 30:1. Normally, BUN and creatinine should show a ratio of 10:1 to 20:1, if the age of the affected person is more than twelve months. For an adult female, the normal creatinine levels in blood ranges from 0.5 to 1.1 mg/dl, or from 44 to 97 μmol/L by the enzymatic method. For the adult male, the normal creatinine levels range from 0.6 to 1.2 mg/dl, or from 53 to 106 μmol/L by the kinetic or enzymatic method and 0.8 to 1.5 mg/dl, or 70 to 133 μmol/L by the older manual Jaffé reaction. The normal serum creatinine (Cr) may vary according to the person’s body muscle mass and the methods used to measure it. are some of the commonly noticed elevated BUN symptoms. Dry-itchy skin, insomnia, nausea, fatigue, etc. The GFR is clinically important as renal function can be assessed with the help of the same.Īn elevated BUN can occur in case of diabetes, congestive heart failure, gastrointestinal bleeding (GI), dehydration, kidney dysfunction, hypertension, etc. Glomeruli are the small capillaries which filter the blood during urine formation. Creatinine levels in urine can help one calculate the creatinine clearance, which reflects the glomerular filtration rate (GFR). For instance, a disproportionate rise in urea level when compared with the creatinine may indicate a prerenal problem such as volume depletion. Measurement of BUN and creatinine helps detect other problems besides those related to the kidney. If more or complete estimation of renal function is to be done, then the blood (plasma) concentration of creatinine along with that of urea has to be taken into consideration. When the kidneys do not filter the blood properly, elevated creatinine levels are observed. Kidneys play an important role in the filtration or removal of creatinine from the blood. Vegetarians usually have low creatinine levels. Men have more muscle mass than women and hence, tend to have higher levels of creatinine than women. It is usually produced at a constant rate by the body, however, it can vary according to the muscle mass. Creatinine is a break-down product of creatine phosphate in muscle. This is the ratio of blood urea nitrogen to serum creatinine. The BUN is roughly one-half (28/60 or 0.446) of the blood urea. In Europe, the whole urea molecule is taken into consideration while in the United States, only the nitrogen component of urea (the blood urea nitrogen or serum urea nitrogen, i.e., BUN or SUN) is measured. Muscle creatine catabolism generates creatinine. Urea is generated from dietary protein and tissue protein turnover. Urea and creatinine are nitrogenous end products of body metabolism.
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